Abstract:Remnant kidney models of chronic kidney disease include the 1/3 nephrectomy (1/3Nx), and 5/6 nephrectomy rats. The 1/3Nx remnant kidney spontaneously atrophies with time, and the 5/6Nx hypertrophies. This disparate remodeling must occur with commensurate vascular changes, examination of which may reveal important molecular pathways and mechanisms underlying changes in renal function. The first step toward realizing this, and the aim of this study, was to characterize the renal vasculature from 1/3Nx, 5/6Nx, an… Show more
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