Abstract of 29th Regional Congress of the ISBT

Merz, Eva-Maria; Mori, Gaia; Hurk, Katja van den; Walraven, S Van; Kraaij, Marian van

doi:10.1111/vox.12792

Cited by 9 publications

(1 citation statement)

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“…We re-coded or imputed missing values for some fields; Table S1 contains these details for all features used for prediction. We also included a composite dietary iron consumption score that was generated for each donor in the RISE dataset as part of a prior secondary analysis of this dataset [14].…”

Section: Data Preprocessing and Formattingmentioning

confidence: 99%

Individualized risk trajectories for iron-related adverse outcomes in repeat blood donors

Russell

Schienker

Custer

2021

Preprint

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Background: Despite a fingerstick hemoglobin requirement and 56-day minimum donation interval, repeat blood donation continues to cause and exacerbate iron deficiency. Study design and methods: Using data from the REDS-II Donor Iron Status Evaluation study, we developed multiclass prediction models to estimate the competing risk of hemoglobin deferral and collecting blood from a donor with sufficient hemoglobin but low or absent underlying iron stores. We compared models developed with and without two biomarkers not routinely measured in most blood centers: ferritin and soluble transferrin receptor. We generated and analyzed individual risk trajectories: estimates of how each donors' risk developed as a function of the time interval until their next donation attempt. Results: With standard biomarkers, the top model had a multiclass area under the receiver operator characteristic curve (AUC) of 77.6% (95% CI 77.3% - 77.8%). With extra biomarkers, multiclass AUC increased to 82.8% (95% CI 82.5% - 83.1%). In the extra biomarkers model, ferritin was the single most important variable, followed by the donation interval. We identified three risk archetypes: fast recoverers (<10% risk of any adverse outcome on post-donation day 56), slow recoverers (>60% adverse outcome risk on day 56 that declines to <35% by day 250), and chronic high-risk (>85% risk of adverse outcome on day 250). Discussion: A longer donation interval reduced estimated risk of iron-related adverse events for most donors, but risk remained high for some. Tailoring safeguards to individual risk estimates could reduce blood collections from donors with low or absent iron stores.

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Section: Data Preprocessing and Formattingmentioning

confidence: 99%

Individualized risk trajectories for iron-related adverse outcomes in repeat blood donors

Russell

Schienker

Custer

2021

Preprint

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Dexchlorpheniramine

2019

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Establishment and application of suspension static method in blood group screening of automated blood group analyzer

Huang

et al. 2023

Sci Rep

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The accuracy of blood group identification is the basis of blood transfusion safety. In order to increase the detection rate of weak agglutination, unexpected antibodies (UAb) and blood subtypes for pre-transfusion testing, the blood group screening process of automated blood group analyzer (ABGA) is ameliorated by introducing one static step and establishing a suspension static method (SSM). One static step was introduced in the blood group screening process of ABGA and three static time conditions were designed: 300 s, 400 s and 500 s, from which the optimal static time was selected and SSM was established; By comparing the detection of weak agglutination and UAb before and after the application of SSM, the feasibility and effect of suspension static method were verified and evaluated. The last two steps of the automatic blood group screening process were replaced with static, light centrifugation and imaging. The optimal static time parameter was selected as 400 s and SSM was established; After the application of SSM, it was verified that: (1) The detection level of weak antibodies (anti-A and anti-B) and weak antigens (weak D phenotype) could be improved by SSM, including antibodies in plasma of known type O samples with 0, 2, 4, 8, 16 and 32 times serial dilutions(simulating weak anti-A and weak anti-B), weak antibodies (anti-B) in plasma of one normal A-type sample and weak antigens on red blood cells (RBC) of 5 weak D phenotype samples (weak D antigen); (2) Three blood donor samples (type A, O and B) with known UAb were detected by SSM. The results showed that SSM could detect both weak antibodies (anti-A and anti-B) and UAb; (3) SSM was applied to detect the samples of 3 A2B and 3 subtype B blood donors and the blood subtypes could be clearly detected; (4) The number of screening samples was 95,314 and 106,814 before SSM (2018) and after (2020) the application of SSM and the positive rate of UAb (63/95,314 and 187/106,814) increased after SSM, discrepancy of which was statistically significant (χ2 = 48.42, P < 0.01). The above results demonstrate that SSM of ABGA is conducive to the detection of weak agglutination, UAb and blood subtypes in blood samples, which can improve the sensitivity of blood group detection and ensure the safety of clinical blood transfusion to a certain extent.

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Abstract of 29th Regional Congress of the ISBT

Cited by 9 publications

References 0 publications

Individualized risk trajectories for iron-related adverse outcomes in repeat blood donors

Individualized risk trajectories for iron-related adverse outcomes in repeat blood donors

Dexchlorpheniramine

Establishment and application of suspension static method in blood group screening of automated blood group analyzer

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