Abstract:The reported clinical activity of lurbinectedin in Small Cell Lung Cancer (SCLC) prompted us to investigate the selective mechanism of this drug in SCLC cell lines. Since lurbinectedin binds the DNA minor groove modifying DNA structure, we hypothesized that it can interfere with transcription regulation. Using SHP-77 SCLC cell line, we investigated the effect of lurbinectedin on transcriptomic profile by microarray approach, at drug concentration that reduced the cell growth rate by 50%. We found only 89 diffe… Show more
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