Abstract:Human papillomavirus (HPV) causes about 5% of all human cancers. The HPV oncoproteins E6/E7 are responsible for the transforming potential of the virus. Although continuous expression of the HPV oncogenes was considered indispensable for HPV-induced carcinogenesis, we and others have demonstrated that in a subset of HPV positive head and neck and cervical cancers, the HPV oncogenes are not expressed (HPV-inactive cancers). Based upon the observation that primary HPV-positive tumors express E6/E7, while metasta… Show more
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