Abstract:Introduction: Generating clinical scale doses of natural killer (NK) cells is currently a challenge for manufacturing CAR-NK cell therapies. Current methods to expand NK cells include irradiated feeder cells that have been engineered to mimic dendritic cells as well as commercially available combinations of antibody & proteins for targeted NK cell expansion. These methods are restrictive due to high costs, scale-up challenges, and licensing restrictions for clinical & commercial applications. We hypoth… Show more
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