Abstract IA27: Functional genetic architecture of serous ovarian cancer

Francis, Kyle; Burston, Helen E.; Mokady, Daphna; Wagner, Melany J.; Medrano, Mauricio; Rottapel, Robert

doi:10.1158/1557-3265.ovca17-ia27

Cited by 1 publication

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“…HGSOC cell lines appear to depend on “quality control” pathways that sense and destroy damaged transcripts and proteins. Nonsense‐mediated decay (NMD) is highly active in HGSOC cell lines . Interference with enzymes that control NMD either genetically or with small molecule inhibitors is deleterious to HGSOC cell lines.…”

Section: How Do We Measure and Target The Genetic Epigenetic And Trmentioning

confidence: 99%

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Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

Bast

Matulonis

Sood

et al. 2019

Cancer

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Substantial progress has been made in understanding ovarian cancer at the molecular and cellular level. Significant improvement in 5‐year survival has been achieved through cytoreductive surgery, combination platinum‐based chemotherapy, and more effective treatment of recurrent cancer, and there are now more than 280,000 ovarian cancer survivors in the United States. Despite these advances, long‐term survival in late‐stage disease has improved little over the last 4 decades. Poor outcomes relate, in part, to late stage at initial diagnosis, intrinsic drug resistance, and the persistence of dormant drug‐resistant cancer cells after primary surgery and chemotherapy. Our ability to accelerate progress in the clinic will depend on the ability to answer several critical questions regarding this disease. To assess current answers, an American Association for Cancer Research Special Conference on “Critical Questions in Ovarian Cancer Research and Treatment” was held in Pittsburgh, Pennsylvania, on October 1‐3, 2017. Although clinical, translational, and basic investigators conducted much of the discussion, advocates participated in the meeting, and many presentations were directly relevant to patient care, including treatment with poly adenosine diphosphate ribose polymerase (PARP) inhibitors, attempts to improve immunotherapy by overcoming the immune suppressive effects of the microenvironment, and a better understanding of the heterogeneity of the disease.

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Section: How Do We Measure and Target The Genetic Epigenetic And Trmentioning

confidence: 99%

“…Nonsense-mediated decay (NMD) is highly active in HGSOC cell lines. 21 Interference with enzymes that control NMD either genetically or with small molecule inhibitors is deleterious to HGSOC cell lines. NMD inhibition triggers cell death through activation of the unfolded protein response.…”

Section: Do Ovarian Cancers Have Distinctive Metabolic Vulnerabilities?mentioning

confidence: 99%