Abstract DP-009: FULL-TERM BIRTHS ARE PROTECTIVE FOR OVARIAN CANCER – WHAT ABOUT INCOMPLETE PREGNANCIES?

Abstract

BACKGROUND: Ovarian cancer is associated with reproductive and hormonal factors including parity, breastfeeding, and use of oral contraceptives. However, the effect of incomplete pregnancies, including both induced and spontaneous abortions, is unclear. The most recent assessments of this association include analyses of two Australian case-control studies and the European Prospective Investigation into Cancer and Nutrition (EPIC) study in which both report no significant association between incomplete pregnancies and risk of ovarian cancer. However, a review of these findings and those included in a systematic review are suggestive of an overall protective effect among women who have had an incomplete pregnancy compared to those who have not. METHODS: To study the incomplete pregnancy-ovarian cancer association in detail, we pooled epidemiologic data from 16 population-based case-control studies from the Ovarian Cancer Association Consortium (OCAC). An incomplete pregnancy was defined as any pregnancy lasting fewer than six months in duration that did not result in a live birth. The effects of ever having an incomplete pregnancy as well as the number of incomplete pregnancies were evaluated using conditional logistic regression after considering potential confounders. Histotype-specific analyses were also conducted to determine the association between incomplete pregnancies and high-grade serous, low-grade serous, mucinous, endometrioid, and clear cell ovarian cancer. RESULTS: A total of 11,217 ovarian cancer cases and 18,588 controls was included in our analysis. We found that women who ever had an incomplete pregnancy had a 17% decreased risk of ovarian cancer compared to those who had not (95% CI 0.78-0.87). Risk of ovarian cancer also decreased with increasing number of incomplete pregnancies (p-trend<0.001). When the association with ever having an incomplete pregnancy was examined by histotype, the protective association was strongest for clear cell ovarian cancer (OR=0.55, 95% CI 0.46-0.66) and less apparent for high-grade serous and mucinous ovarian cancers (OR=0.94, 95% CI 0.88-1.01 and OR=0.89, 95% CI 0.74-1.07, respectively). The same patterns are observed for full-births. CONCLUSIONS: Incomplete pregnancies appear to be associated with a decreased risk of ovarian cancer, particularly for the clear cell histotype. Full births are more protective than incomplete pregnancies. However, these findings suggest that the hormonal milieu during pregnancies of short gestation may be sufficient to confer some protection against ovarian carcinogenesis. Citation Format: Alice W. Lee, Stacey Rosenzweig, Penelope Webb, Malcolm C. Pike, Celeste Leigh Pearce on behalf of the Ovarian Cancer Association Consortium.. FULL-TERM BIRTHS ARE PROTECTIVE FOR OVARIAN CANCER – WHAT ABOUT INCOMPLETE PREGNANCIES? [abstract]. In: Proceedings of the 12th Biennial Ovarian Cancer Research Symposium; Sep 13-15, 2018; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2019;25(22 Suppl):Abstract nr DP-009.