Abstract:Background: Previous studies have demonstrated that engineered 3D stem cells could greatly increase the safety and stability as multifunctional biologics for in vivo inoculation. We designed a kind of novel 3D-pluripotent stem cell biologics which achieved promising results in animal experiments of mice and rhesus monkeys. To evaluate the safety and efficacy of this therapy in clinic, we conducted this phase I study in patients with advanced non-small-cell lung cancer (NSCLC) after standard treatment failure.
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