Abstract:The carbohydrate antigen sialyl-Lewis A (sLea), also known as CA19.9, is widely expressed on epithelial tumors of the gastrointestinal tract, on breast cancer cells, and also on small cell lung cancer cells. sLea serves as a ligand for epithelial leukocyte adhesion molecules and over-expression of sLea appears to be a key event in invasion and metastasis of many tumor cells. Since tumor cells expressing sLea are highly susceptible to antibody mediated lysis mechanisms, sLea presents an attractive molecular tar… Show more
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