Abstract:Introduction: The epidermal growth factor receptors (EGFR) family stimulates a number of signal transduction cascades that regulate diverse cellular processes, such as proliferation, differentiation, survival, migration, and adhesion. These signaling pathways are important in normal cellular homeostasis but aberrant activation of the EGFR members can cause carcinogenesis. The carcinogenic role of HER3 and HER4 has been seen in gastric cancer. In this study, the prognostic effect of HER3 is evaluated in gastric… Show more
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