Abstract:Breast cancer subtype distribution differs between populations with dissimilar genetic ancestry backgrounds. Several breast cancer risk single nucleotide polymorphisms (SNPs) were discovered in individuals of European and Asian origin. Hispanic/Latina women remain underrepresented in studies and public databases. The 6q25 locus contains multiple breast cancer risk-associated SNPs. Some SNPs within this region have been associated with the expression of genes (eQTLs), such as the Estrogen Receptor 1 gene (ESR1)… Show more
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