Abstract:Numerous lines of evidence point to the tumor promoting properties of prostaglandin (PG)E2. Preclinical studies have demonstrated the ability of both vitamin D (vitD) and celecoxib to downregulate the ecisanoid. We hypothesized that the two agents would work synergistically. The purpose of the study was to determine the dose dependent effects of vitD, with or without celecoxib. 24 women were prospectively enrolled and randomized in double blind fashion for one month (postmenopausal) or one menstrual cycle (pre… Show more
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