Abstract:Glioblastoma multiforme (GBM) is the highly invasive primary tumors with a poor prognosis despite current surgical, radiation and chemotherapy approaches. Proteasome inhibitor, an approved drug for treatment of hematological cancer is currently being tested in clinical trials against various malignancies, including GBM. The pro-apoptotic and antitumorigenic protein NAG-1(nonsteroidal anti-inflammatory drug-activated gene-1) is a divergent member of the transforming growth factor-beta (TGF-beta) superfamily. We… Show more
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