Abstract:The ability of cancer cells to survive and grow at primary and metastatic sites is influenced to a large degree by the surrounding cells in the tumor environment. In this process, tumor cells secrete signals that recruit specific cell types to their immediate vicinity and induce these cells to produce factors critical to tumor development, while the surrounding normal tissue, or stroma, detects and responds to developing lesions. While the clinical importance of this complex dialogue between the tumor and the … Show more
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