Abstract:Naturally isolated products continue to play a significant role in anticancer drug discovery. In line with our interest in small molecule compounds which effect epigenetic gene regulation, we are interested in the structural and biological properties of the natural product Psammaplin A. While it has been implicated as an inhibitor of numerous targets such as mycothiol-S-conjugate amidase, topoisomerase II and aminopeptidase N, studies by Crews and co-workers showed it to be an extremely potent inhibitor of bot… Show more
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