Abstract B16: The effect of e-cigarette exposure on airway epithelial cell gene expression and transformation.

Park, Stacy J.; Walser, Tonya C.; Perdomo, Catalina; Wang, Teresa; Pagano, Paul C.; Liclican, Elvira L.; Krysan, Kostyantyn; Larsen, Jill E.; Minna, John D.; Lenburg, Marc E.; Spira, Avrum; Dubinett, Steven M.

doi:10.1158/1078-0432.14aacriaslc-b16

Cited by 27 publications

(19 citation statements)

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“…Although the nature and degree of harm associated with e-cigarette use is not fully known, emerging evidence suggests potential acute 7 and chronic 8 effects. One significant concern is the potential for e-cigarettes to serve as a precursor to combustible cigarette use, 9–10 which is an enormous public health burden.…”

Section: Background and Objectivesmentioning

confidence: 99%

E‐cigarette use of young adults motivations and associations with combustible cigarette alcohol, marijuana, and other illicit drugs

Temple

Shorey

et al. 2017

American J Addict

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Background and Objectives Although the prevalence of e-cigarette use among adolescents and young adults has caught up to or eclipsed that of combustible cigarette use, there is relatively little known about (a) the link between e-cigarettes and other substances and (b) the reasons underlying this increase in e-cigarette use. To address this gap in knowledge, the current study examined associations between e-cigarette use and other substances and identified motives for e-cigarette use among young adults. Methods Participants included an ethnically diverse sample of African American, White, and Hispanic young adults (N=662; 61% female) who were participating in an ongoing survey-based longitudinal study of health and risky behaviors. Results Hispanic, White, and male young adults reported significantly greater past year e-cigarette use compared to their African American and female counterparts. Bivariate correlations showed that use of e-cigarettes was positively associated with use of combustible cigarettes, alcohol, marijuana, cocaine, amphetamines, inhalants, hallucinogens, ecstasy, and misuse of over-the-counter and prescription medications. Furthermore, e-cigarette users reported a higher prevalence of substance use relative to those who did not use e-cigarettes. The taste of e-cigarettes was identified as an important motive for use. Conclusions and Significance Although the potential harm associated with e-cigarettes remains largely unknown, e-cigarettes appear to be a risk marker for the use of substances that are known to pose substantial health problems. Health care providers should screen for e-cigarette use, and youth substance use prevention programs should target the reduction of e-cigarette use with particular attention to addressing their taste appeal.

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Section: Background and Objectivesmentioning

confidence: 99%

E‐cigarette use of young adults motivations and associations with combustible cigarette alcohol, marijuana, and other illicit drugs

Temple

Shorey

et al. 2017

American J Addict

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“…However, it is unknown what happens to the lung when these constituents are heated and inhaled. E-cig heated PG can be converted to propylene oxide (1, 153), which is an irritant and an International Agency for Research on Cancer group 2b carcinogen (possibly carcinogenic to humans) (154). Heated VG and PG can be converted to acrolein, acetaldehyde, and formaldehyde, which also are known strong irritants that affect inflammation (155–157).…”

Section: Introductionmentioning

confidence: 99%

A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation

Shields

Berman

Brasky

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

107

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The use of electronic cigarettes (e-cigs) is increasing rapidly, but their effects on lung toxicity are largely unknown. Smoking is a well-established cause of lung cancer and respiratory disease, in part through inflammation. It is plausible that e-cig use might affect similar inflammatory pathways. E-cigs are used by some smokers as an aid for quitting or smoking reduction, and by never smokers (e.g., adolescents and young adults). The relative effects for impacting disease risk may differ for these groups. Cell culture and experimental animal data indicate that e-cigs have the potential for inducing inflammation, albeit much less than smoking. Human studies show that e-cig use in smokers is associated with substantial reductions in blood or urinary biomarkers of tobacco toxicants when completely switching and somewhat for dual use. However, the extent to which these biomarkers are surrogates for potential lung toxicity remains unclear. The FDA now has regulatory authority over e-cigs and can regulate product and e-liquid design features such as nicotine content and delivery, voltage, e-liquid formulations, and flavors. All of these factors may impact pulmonary toxicity. This review summarizes current data on pulmonary inflammation related to both smoking and e-cig use, with a focus on human lung biomarkers.

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“…The potential interactions of ENDS with cytotoxic cancer therapeutics are also unknown, and there is in vitro evidence that nicotine stimulates proliferation, migration, invasion, and angiogenesis and decreases cancer cell death from irradiation and chemotherapy, raising concern as to whether prolonged ENDS use might have similar effects in patients with cancer (78). Moreover, researchers have found that human bronchial cells grown in medium exposed to e-cigarette aerosol showed a similar pattern of gene expression to those grown in medium exposed to tobacco smoke (79). Whereas ENDS may have unknown adverse effects in cancer patients, the adverse effects of smoking are not in question.…”

mentioning

confidence: 99%

Electronic Nicotine Delivery Systems: A Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology

Brandon

Goniewicz

Hanna

et al. 2015

Clinical Cancer Research

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Combustible tobacco use remains the number one preventable cause of disease, disability, and death in the United States. Electronic nicotine delivery systems (ENDS), which include ecigarettes, are devices capable of delivering nicotine in an aerosolized form. ENDS use by both adults and youth has increased rapidly, and some have advocated these products could serve as harm-reduction devices and smoking cessation aids. ENDS may be beneficial if they reduce smoking rates or prevent or reduce the known adverse health effects of smoking. However, ENDS may also be harmful, particularly to youth, if they increase the likelihood that nonsmokers or formers smokers will use combustible tobacco products or if they discourage smokers from quitting. The American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) recognize the potential ENDS have to alter patterns of tobacco use and affect the public's health; however, definitive data are lacking. AACR and ASCO recommend additional research on these devices, including assessing the health impacts of ENDS, understanding patterns of ENDS use, and determining what role ENDS have in cessation. Key policy recommendations include supporting federal, state, and local regulation of ENDS; requiring manufacturers to register with the FDA and report all product ingredients, requiring childproof caps on ENDS liquids, and including warning labels on products and their advertisements; prohibiting youth-oriented marketing and sales; prohibiting child-friendly ENDS flavors; and prohibiting ENDS use in places where cigarette smoking is prohibited.

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Abstract B16: The effect of e-cigarette exposure on airway epithelial cell gene expression and transformation.

Cited by 27 publications

References 0 publications

E‐cigarette use of young adults motivations and associations with combustible cigarette alcohol, marijuana, and other illicit drugs

E‐cigarette use of young adults motivations and associations with combustible cigarette alcohol, marijuana, and other illicit drugs

A Review of Pulmonary Toxicity of Electronic Cigarettes in the Context of Smoking: A Focus on Inflammation

Electronic Nicotine Delivery Systems: A Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology

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