Abstract:The process of canalization whereby phenotypic traits are buffered against stochastic fluctuations to preserve the evolutionarily advantageous “normal” level can be potentially exploited during cancer progression. Release of canalization through pharmacologic or genetic down-regulation of Hsp90 removes this buffer and increases variation, allowing for rapid changes in traits as evidenced in Drosophila, Arabidopsis, and maize. If cancer is viewed as a Darwinian struggle of the premalignant cell to acquire the h… Show more
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