Abstract:PIN-2 is a novel immunomodulatory agent derivatized from a transactivator protein. We have shown its activity to induce maturation of monocytes into dendritic cells and translational proof of principle using an aggressive metastatic murine mammary cancer model. The purpose of the present studies was to further elucidate the activity and mechanism of action of PIN-2 alone or in combination with other agents in the treatment of solid malignancy.
Murine mammary carcinoma was established with syngen… Show more
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