“…For the CNVs detected by the CIRCNV method, we further find that these CNVs contain many biological genes associated with ovarian cancer. For instance, the CNVs detected in sample EGAR00001004802_2053_1 contain cancer-associated genes such as ELOVL7 [10] located at 5q12.1, IFNB1 [44] located at 9p21.3, BAG1 [45] located at 9p21.1, RECK [46] located at 9p13.3, DAPK1 [47], CTSL [48], and CCRK [49] located at 9q21.33, SYK [50] located at 9q22.2, and NR4A3 [51] and TMEFF1 [52] located at 9q22.33. Similarly, the CNVs detected in sample EGAR00001004836_2561_1 also contain many cancer-associated genes, such as CD80 [53], GSK3B [54], FSTL1 [55], CASR [56], PARP9 [57], and PARP15 [58] located at 3q13.33.…”