Abstract:Dynamic signaling complexes employ multiple post-translational modifications (PTMs) to convey intracellular messages that govern cell division. We seek to model these mechanisms to understand the action of tyrosine kinase inhibitors (TKIs) as anti-cancer drugs. Advanced proteomics and informatics approaches allow proteome-wide dissection of TKI-associated signaling complexes and decoding the cross-talk among PTM signaling network. Sequential enrichment of PTM proteomics and MaxQuant were used to quantitatively… Show more
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