Abstract:Due to the rarity of ovarian cancer stem cells (OvCSC; <0.2% total population), we developed a 3D hanging drop array model, in which as few as 10 OvCSCs (isolated from primary malignant ascites based on ALDH+ CD133+) can be stably incorporated into spheroids for study of drug sensitivity and tumor biology. Our platform can be utilized to: i) quantify drug sensitivity of chemotherapeutic agents in the context of OvCSCs; ii) distinguish drug responses for the same drugs between several patient samples; th… Show more
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