Abstract:The myogenic transcription factor Pax3 plays an essential role in early skeletal muscle development and is a key factor in Alveolar rhabdomyosarcoma (ARMS), a childhood solid muscle tumor. ARMS is associated with an unfavorable prognosis due to the propensity for wide dissemination and a poor response to chemotherapy. The characteristic translocation in ARMS results in the fusion of the 5' Pax3 sequences to the 3' FOXO1a sequences to encode a fusion protein, Pax3‐FOXO1a. Post translational modifications such a… Show more
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