Abstract:Introduction: Nearly 35% of children with acute myeloid leukemia (AML) die, despite aggressive but toxic and nonspecific therapies. New approaches to find and drug pediatric AML targets are clearly needed. Super enhancers (SEs), large regions of highly active chromatin, define cell state and cell identity by regulating oncogenes in many cancers. Recent enhancer profiling of 66 adult AML patient samples revealed SE-defined, prognostically relevant subgroups. An SE was at the retinoic acid receptor alpha (RARA) … Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.