Abstract:Reliable prediction of recurrence in stage II colorectal cancer (CRC) patients is a major unresolved clinical need as recurrence is often the ultimate cause of death in these individuals. Several mRNA and DNA prognostic markers have been evaluated and, to date, none have been recommended by oncology groups due to poor specificity and sensitivity. MicroRNA (miRNA) have been shown to regulate fundamental cellular processes and have been implicated in several cancer types, including CRC. We used a microarray plat… Show more
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