Abstract:Highly recurrent somatic mutations in the isocitrate dehydrogenase (IDH) 1 and 2 enzymes have been identified in a variety of tumor types including GBM and glioma subtypes, acute myelogenous leukemia, chondrosarcoma, and cholangiocarcinoma, among others. Mutant IDH proteins gain a novel function: the production of the “oncometabolite” 2-hydroxyglutarate (2-HG), which accumulates in the tumors of affected patients. The similarity of 2-HG to a-ketoglutarate, a cofactor required for the function of a large number… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.