Abstract:Metastatic melanoma is highly fatal. Within the tumor microenvironment, the role of cancer-associated fibroblasts (CAFs) in melanoma metastasis and progression is relatively understudied. Matricellular proteins of the CCN family are emerging targets for cancer therapy. Anti-CCN2 (CTGF) strategies are under clinical development; however, the role of CCN1 (cyr61) in cancers is unclear. Herein, we use bioinformatic analyses to report that the CCN1 is overexpressed, in a fashion independent of BRAF mutational stat… Show more
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