Abstract:Introduction: Differences in tumor heterogeneity, particularly the tumor microenvironment have not yet been explored as potential molecular features underlying cancer disparities. Molecular profiling of bulk tissue specimens using methods such as whole-transcriptome sequencing are limited in their ability to resolve fine grain molecular signatures and hinder our utility to dissect underlying biology of individual tumors. Although informatics approaches are available that attempt to disentangle tissue heterogen… Show more
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