Abstract:Background: Colorectal cancer (CRC) is the second leading cause of cancer-associated deaths in the US. Evidence from several studies suggests that the colonic immune environment can influence the risk of CRC. Bacterial minicells (MC) are spherical, non-viable nano-sized particles derived from genetically-engineered E. coli (Vaxiion Therapeutics, Inc). MC contain all of the components of parental bacteria they are derived from with the exception of the chromosome, making them non-infectious. MC used here have b… Show more
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