Abstract: A Novel Technique for Tissue Engineering Periosteum Using Three-Dimensional Bioprinting

Alba, Brandon; Swami, Pooja; Tanna, Neil; Grande, Daniel

doi:10.1097/01.gox.0000546950.64387.8d

Cited by 6 publications

(3 citation statements)

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“…A comprehensive review analyzing the application of BTE for orthopedic trauma according to the different anatomical sites, showed its usefulness to treat bone trauma in a patient-specific manner [192]. Alba et al [193] developed a new method to engineer periosteum tissue by printing periosteal derived cells (PDCs) mixed with alginate on collagen scaffolds. The presence of collagen contributed to maintain the structural integrity and osteogenic differentiation of PDCs, which was demonstrated by osteocalcin and alkaline phosphatase gene expression.…”

Section: D Bioprinting Applications To Treat Bone Defectsmentioning

confidence: 99%

“…A multi-component bioink, constituted by wood-based nano-cellulose and bioactive glass to strengthen gelatin-alginate bioinks, was tested and resulted effective in sustaining bone cell viability, proliferation, and osteodifferentiation [193].…”

Section: D Bioprinting Applications To Treat Bone Defectsmentioning

confidence: 99%

“…In Table 2, we present some works potentially relevant for their clinical implications, where 3D bioprinting resulted as useful in repairing bone defects. [193,206] EBB by piston-driven system…”

Section: D Bioprinting Applications To Treat Bone Defectsmentioning

confidence: 99%

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Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction of three-dimensional (3D) bioprinting. Bone tissue engineering is a branch of regenerative medicine that aims to find new solutions to treat bone defects, which can be repaired by 3D printed living tissues. Its aim is to overcome the limitations of conventional treatment options by improving osteoinduction and osteoconduction. Several techniques of bone bioprinting have been developed: inkjet, extrusion, and light-based 3D printers are nowadays available. Bioinks, i.e., the printing materials, also presented an evolution over the years. It seems that these new technologies might be extremely promising for bone regeneration. The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone bioprinting such as selecting cell sources and attaining a viable vascularization within the newly printed bone. The main bioprinters currently available on the market and their characteristics have been taken into consideration, as well.

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Section: D Bioprinting Applications To Treat Bone Defectsmentioning

confidence: 99%

Section: D Bioprinting Applications To Treat Bone Defectsmentioning

confidence: 99%