Abstract:Introduction and Objective: Although Paclitaxel has demonstrated antitumor activity against several cancers, the acquisition of resistance during treatment remains a significant problem. Several potential mechanisms were proposed and the recent studies determined that drug resistance may involve histone H3 acetylation. Histone deacetylases (HDACs) are overexpressed in prostate cancer (PCa) and HDAC inhibitors have greater anti-proliferative activity against prostate and breast cancer models. We have investigat… Show more
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