Abstract:Metastatic progression of cancer, which is responsible for 90% of patients death, results from tumor cells dissemination out of the primary tumor throughout the body. During the first step of this process -that consists in invasion of the peritumoral stroma- cancer cells can adopt 1) a single cell mode of invasion, in which cell have lost cell-cell junctions to move individually, 2) or a collective mode of invasion where cells maintain their cell-cell junctions to move as a cohort in which Leader cells at the … Show more
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