Abstract 74

Abstract

nox-4 activity resulted in decreased hydrogen peroxide production and decreased production of oxidant inducible monocyte chemoattractant protein-1. ConClusions:These are the first reported results to demonstrate the significant contribution of dicer activity and miR production in promoting hemangioendothelioma growth in vivo. These are also the first reported results of miR21a-3p targeting nox-4 mRNA and inhibiting reactive oxygen species production in endothelial cells. Collectively, these results indicate that targeting microRNA and specifically, miR-21a-3p, represent potential therapeutic strategies for the treatment of endothelial cell tumors including hemangioma and hemangioendothelioma.

Distally-based free anterolateral thigh flap with a modified vena comitans

“…Previously described methods for pedicle lengthening include vein grafts, arteriovenous loops, and arteriovenous bundle grafts. Recent studies have reported ALT flap pedicle length extension within the operative field [7-10].…”

“…If the length of the ALT flap pedicle is insufficient despite adequate preoperative planning, pedicle length extension is required. Recent studies have reported pedicle length modification within the ALT operative field [7-10]. We attempted pedicle length extension with the distal descending branch in a case of insufficient pedicle length in the proximal direction because the perforator emerged from a quite proximal portion of the descending branch.…”