Abstract 6634: Digital and spacial characterization of PD-L1 expression and IVD assay performance in the immune landscape of head and neck squamous cell carcinoma: A multimodal approach
Abstract:The anti-PD-L1 antibody (22C3) is used as a companion diagnostic for successful checkpoint inhibitor therapy in head and neck squamous cell carcinoma. The positive predictive value of this assay, however, is less than ideal as a high PD-L1 score does not necessarily associate with a good response, and a good response may be seen with a low or negative PD-L1 score. In principle, this could be due to lack of accuracy and/or precision of the assay, as well as biological factors, such as variable expression across… Show more
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