Abstract:Based on preclinical and clinical study data, anti-programmed cell death protein 1 (PD-1) drugs Pembrolizumab (P), and Nivolumab (N) have been considered equivalent in terms of response efficacy. Both the antibodies have IgG4 backbone but vary considerably in terms of the PD-1 epitopes they bind to.. Given that there is almost no overlap between the PD-1 binding sites there is a definite possibility of nuanced drug-dependent differences in patient response to treatment. These differences would not be possible … Show more
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