Abstract 637: Spatial transcriptomics for FFPE characterizes the molecular and cellular architecture of malignant changes in pancreatic pre-malignant lesions
Abstract:We have optimized an experimental and computational pipeline to adapt spatial transcriptomics (ST) approaches based upon the Visium (10x Genomics) technology to infer cellular composition and intercellular interactions of FFPE clinical specimens. We apply this technology to deliver an approach to examine pancreatic intraepithelial neoplasia (PanIN) to identify intrinsic and extrinsic mechanisms that are associated with the progression of these pre-malignant lesions to invasive carcinoma. Currently, most pancre… Show more
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