Abstract:Background: All prostate cancers first manifest as androgen dependent tumors and most patients are initially treated with surgery or radiation. About 30% of these patients return to clinic with recurrent prostate cancer that initially responds to androgen ablation therapy (ADT). Unfortunately, almost all of them fail ADT and develop castrate resistant disease (CRPC) that responds poorly to most cancer therapies and progress to often lethal metastatic CRPC (mCRPC). There are accumulating evidence that at a cert… Show more
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