Abstract:Acute lymphoblastic leukemia (ALL) is the most commonly diagnosed cancer in pediatric patients. Recent advances have allowed for improved efficacy of treatment allowing 95% of patients to achieve remission following chemotherapy. However, nearly 20% will have a second recurrence that is often more aggressive and difficult to treat. One reason for this high rate of relapse may be due to the role of the bone marrow microenvironment (BM) consisting of osteoblasts, endothelial cells, adipocytes, and stromal cells … Show more
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