Abstract:The influence of genetics on atherosclerosis development remains unclear. Association of single-nucleotide polymorphisms (SNPs) with early-onset coronary artery disease (EOCAD), as well as with carotid intima-media thickness (CIMT), and systemic microvascular reactivity was examined in 52 patients with EOCAD (45 ±3 years old) and 35 age-matched controls. SNPs in ACE, TNF-α (-308G/A, -238 G/A), IFN-γ (+874 A/T), MMP-9 (-1562 C/T), IL-10 (-1082 A/G, -819 C/T, 592 C/A), NOS3 (894 G/T), ApoA1 (rs964184), and TGF-β… Show more
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