Abstract:Purpose of this study is evaluating the effect produced by targeting Heparan Sulfated Proteoglycan (HSPG) by specific branched peptides, on cancer cell adhesion, migration and drug-resistance.
In previous papers we reported on synthesis and biological activity of tetra-branched peptides (NT4) containing the sequence of human neurotensin (NT), coupled to different tracers or drugs. Differently to monomeric NT, NT4 peptides bind with high selectivity to cells and tissues from different human cance… Show more
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