Abstract 5274: Role of obesity and dietary chemopreventive nutrients on risk for breast cancer among ethnically diverse women

Abstract

Dietary factors have been inconsistently associated with breast cancer risk among various ethnicities. Diet however, may influence breast cancer through mechanisms of obesity. The purpose of this study was to compare intake of dietary chemopreventive nutrients and obesity across three racial/ethnic groups: Latina, African American and Asian women. Methods: Eighty subjects from Inland Empire, California were enrolled into the study from five different sites. Dietary intake was assessed using a validated food frequency questionnaire. The questionnaire includes 19 adjustment questions used to modify food-item responses in regard to fat, fiber, and sodium intake followed by 122 specific food item-lines that capture frequency and serving sizes for select foods. Women also completed a demographic and breast cancer survey. Chi-square tests were used for categorical variables, ANOVA, and Kruskal-Wallis one-way analysis of variance was used for nutrient variables. Results: The age of the study population ranged from 24 to 79. Subjects included 30 Latina, 35 African American and 15 Asian women. The mean body mass index for Latina, African American and Asian women was 26.8±4.2, 30.8±7.24, 24.41±3.85 respectively. Mean fat percent for the three races was 34.21±5.80 for Latina, 41.57±6.33 for African American and 35.5±8.74 for Asian. African American women were significantly (p=0.001) more obese compared to Latina and Asian women. Total breast cancer cases for Latina is 3, African American 6 and Asian 2. Family history of reported breast cancer among Latina, African American and Asian was 0, 11, 0 respectively. There was a significant difference among racially ethic groups in alcohol consumption (p=0.001), alpha carotene (p=0.005), beta-carotene (p=0.031), beta-Cryptoxanthin (p=0.022), Lycopene (p=0.000) MUFA (p=0.017), PUFA (p=0.000) animal protein (0.49) and total Vitamin A (0.044). Conclusion: Significant differences were found in obesity and dietary intake of chemopreventive nutrients among the three racial groups. African Americans had higher rates of obesity and lower consumption of total vegetable intake. This data is consistent with the general US population data in terms of obesity and risk for breast cancer. Further studies will include larger sample size to identify specific nutrients that may protect against breast cancer risk among diverse populations. Citation Format: Padma P. Tadi Uppala, Sozina Katuli, Alfredo Mejia, Sherine Brown-Fraser, Brian Yuen Yau Wong, Ryan Hayes, Maheswari Senthil, Carlos Garberoglio. Role of obesity and dietary chemopreventive nutrients on risk for breast cancer among ethnically diverse women [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 5274.