Abstract 52

Abstract

PurPose: Studies from NYU revealed that following nasoalveolar molding/gingivoperiosteoplasty (GPP) 60% of patients did not require an alveolar bone graft. In our lab midface animal growth was not detrimentally affected after BMP-2 healing of alveolar clefts. In this study, we performed a similar procedure to NYU with alveolar molding/GPP but with BMP-2 on a resorbable matrix for primary alveolar repair in the infant. We compared long-term follow-up (10 years) for 1) No GPP, 2) GPP only or 2) GPP with BMP-2 by analyzing alveolar bone, tooth eruption, and maxillary growth. Methods:For the three primary unilateral cleft repair patient groups: 1) No GPP (n=15), 2) GPP only (n=15) or 2) GPP with BMP-2 (n=10) we performed follow-up studies at least 10 years after the procedure. There was one GPP patient lost to follow-up. We recorded need for secondary alveolar bone grafting, timing of tooth eruption, and clinical evidence of maxillary hypoplasia. New-Tom scans were used to analyze dentition, bone volume and bone density.