Abstract 516: Pharmacological Inhibition of Phosphatase and Tensin Homolog Ameliorates Adipose Tissue Inflammation and Increases Splenic Regulatory B and T Cells in Rats With Metabolic Syndrome
Abstract:Objectives:
B cells have emerged as a critical player in innate and adaptive immune responses. However, little is known about the role of B cells in obesity- and/or stress-induced immune responses. We previously reported that restraint stress exacerbates cardiac and adipose tissue pathology via β-adrenergic signaling in rats with metabolic syndrome (MetS). Phosphatidylinositol 3’-kinase (PI3K)/Akt pathway regulates interleukin-10 production by B cells. Phosphatase and tensin homolog (PTEN) is a lip… Show more
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