Abstract:Establishment of an immunosuppressive microenvironment is one mechanism of tumor immune escape. Elevated levels of 5’-deoxy-5’-methylthioadenosine (MTA) were detected in various tumor entities and spurred interest as putative immuno-inhibitory metabolic dysregulation. Loss of MTA phosphorylase (MTAP) activity in tumor cells was identified as major cause of MTA accumulation. Lack of MTAP expression is associated with an inferior response towards adjuvant interferon-α therapy and a higher risk for metastatic dis… Show more
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