Abstract 4903: Microarray gene expression analysis of human prostate cancer PC-3 cells targeted by Salmonella typhimurium A1-R

Abstract

The transcriptional profile of PC-3 human prostate cancer cells infected with tumor-targeting Salmonella typhimurium A1-R (A1-R) was analyzed with by microarray. PC-3 is highly sensitive to A1-R. Numerous genes involved in diverse cellular processes, including apoptosis, necrotic cell death, neutrophil chemotaxis and innate immunity were significantly up-regulated by A1-R bacterial infection. Such up-regulated genes include TNF-a, Fos and JUN which are involved in cell death and IL-1A and CXCL which are involved in neutrophil chemotaxes. Knowledge of the up-regulated gene profile will be exploited for enhancing prostate tumor targeting by A1-R. Keywords: Salmonella typhimurium A1-R, human prostate cancer, microarray, apoptosis, necrotic cell death, neutrophil chemotaxis, tumor-targeting. Citation Format: Ming Zhao, Wen Wu, Chongyi Lu, Yong Zhang, Robert M. Hoffman, Hui Qi, Meng Yang, Yanqin Gu, Yiyu Lu, Shibing Su, Hui Zhang, Qianmei Zhou, Qilong Chen. Microarray gene expression analysis of human prostate cancer PC-3 cells targeted by Salmonella typhimurium A1-R. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4903. doi:10.1158/1538-7445.AM2015-4903