Abstract:Actinins are cytoskeleton proteins that crosslink actin filaments. Evolution of the actinin family resulted in the formation of calcium-insensitive muscle isoforms (actinin-2 and- 3) and calcium-sensitive non-muscle isoforms (actinin-1 and -4) with regard to their actin-binding function. Although the non-muscle actinin isoforms show 87% amino acid identity, they are currently viewed as distinct entities. Each isoform is reported to exert distinct effects on cell migration, adhesion and proliferation depending … Show more
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