Abstract:Background: Hepatocellular carcinoma (HCC) typically occurs in patients with chronic liver disease. Such diseases create a demand for liver regeneration due to injury, which in turn promotes upregulation of c-Met, a receptor for hepatocyte growth factor (HGF) involved in wound healing, leading to increased cellular proliferation, survival, and mobilization. c-Met is the product of the proto-oncogene MET, so increased c-Met activity not only effects wound healing but can also contribute to the development and p… Show more
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