Abstract:Background
In routine pathology, in situ quantification of protein in formalin-fixed, paraffin-embedded (FFPE) tissue is limited to immunohistochemistry (IHC) which is semi-quantitative at best. Accurate and robust measurement of protein expression in FFPE samples, without loss of morphological information, is currently not achievable. Quantitative protein assessment of FFPE tissue can be destructive, and/or time consuming with risk of analyzing non-relevant tissue due to heterogeneity.
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