“…MSI status was determined from analysis of 114 intronic loci, and TMB was assessed on 1.1 megabases (Mb) of sequenced DNA with TMB low defined as 6 mut/Mb [27,28]. Genome-wide LOH status was calculated as the percentage of the tumor genome displaying LOH based off the CNA pipeline, and LOH high was classified as !16% based on clinical data derived from the ARIEL2 Part 1 trial (ARIEL2, NCT01891344) [29].…”