Abstract 4525: Dynamic changes in patterns of ganglioside expression characterize maturation of cytotoxic T cells and natural killer cells into effector cells and suggest a close relationship between the two cell types
Abstract:Gangliosides are glycosphingolipids that play important regulatory roles in cell signaling. Their patterns of expression during human lymphoid cell development and differentiation, however are not not known. Here, we used the ganglioside-binding B subunits of E. coli enterotoxins (LT-IIa-B, LT-IIb-B and LT-IIc-B) as molecular probes to dissect the membrane ganglioside composition of human CD8+ T cells and NK cells, two important players in the anti-tumor response. Human normal PBMC isolated from leukoreduction… Show more
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