Abstract:Background: PD-1/PDL-1 inhibitors are active in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) and improve progression-free survival (PFS) and overall survival (OS) when added to chemotherapy, even in tumors with low PDL-1 expression. We recently reported that for most agents assessed in most solid tumors, PFS and OS curves follow first order kinetics (Stewart Crit Rev Oncol Hematol 2020 Apr;148:102896; Stewart Crit Rev Oncol Hematol 2020 Sep;153103039). On log-linear plots, some curves a… Show more
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